Interaction of Platelets and Anidulafungin against Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
Anidulafungin in combination with amphotericin B against Aspergillus fumigatus.
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in co...
متن کاملPharmacodynamics of anidulafungin against clinical Aspergillus fumigatus isolates in a nonneutropenic murine model of disseminated aspergillosis.
Azole resistance is an emerging increasing problem in Aspergillus fumigatus that results in treatment failure. Alternative treatments may improve the therapeutic outcome in patients with azole-resistant invasive aspergillosis (IA). Little is known about the in vivo efficacy of the echinocandin anidulafungin (AFG) in IA. The in vivo efficacy of 2.5, 5, 10, and 20 mg/kg of body weight AFG was ass...
متن کاملIdentification of Aspergillus fumigatus Surface Components That Mediate Interaction of Conidia and Hyphae With Human Platelets.
BACKGROUND Platelets were recently identified as a part of innate immunity. They are activated by contact with Aspergillus fumigatus; putative consequences include antifungal defense but also thrombosis, excessive inflammation, and thrombocytopenia. We aimed to identify those fungal surface structures that mediate interaction with platelets. METHODS Human platelets were incubated with Aspergi...
متن کاملPotential synergistic activity of antimycotic substances in combination with human platelets against Aspergillus fumigatus.
of the two tested compounds. While the safety of squalamine has been demonstrated in clinical studies, no in vitro or in vivo toxicity studies have been reported for synthesized aminosterols. Nevertheless, since ASDs were reported to act as membrane disruptors, such a wide antimicrobial spectrum may encompass a potential toxicity that should be further investigated. Overall, we have demonstrate...
متن کاملPrevalence of specific immunoglobulin E and G against Aspergillus fumigatus in patients with asthma
Background and Purpose: Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) a...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2012
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01534-12